SS-31 50MG

Description

Champion Peptides SS-31 50MG: Premium Mitochondrial Target Peptide for Advanced Research

Advance your cellular energy research with Champion Peptides’ premium SS-31 50MG. This highly purified, laboratory-grade mitochondrial compound targets cardiolipin, combats oxidative stress, and optimizes ATP production.

Advanced Mitochondrial Restoration and Cellular Longevity

Mitochondrial dysfunction drives cellular aging, metabolic decline, and many degenerative pathologies. Researchers studying therapeutic interventions at the molecular foundation of the cellular powerhouse find SS-31 — also known as Elamipretide or Bendavia — to be a highly promising agent in modern biochemistry. Champion Peptides offers high-quality SS-31 synthesized to rigorous standards of purity. This formulation is prepared specifically for in vitro and in vivo research applications.

SS-31 is a small, cell-permeable tetrapeptide with a specific amino acid sequence (D-Arg-Dmt-Lys-Phe-NH2). Most traditional antioxidants fail to penetrate the mitochondrial membrane. SS-31 is different. It selectively localizes to the inner mitochondrial membrane (IMM). Once there, it binds directly to cardiolipin — a unique phospholipid best for mitochondrial cristae structure and electron transport chain (ETC) assembly. Stabilizing cardiolipin helps preserve structural integrity, optimizes oxidative phosphorylation, and curtails the pathological production of reactive oxygen species (ROS).

When looking to buy SS-31 online for your laboratory, Champion Peptides offers an excellent combination of purity, stability, and documented testing. Our SS-31 for sale is manufactured under strict quality control protocols. This ensures your experimental outcomes remain consistent and free from confounding variables.

The Molecular Mechanism of Action: Stabilizing Cardiolipin

Understanding the specialized mechanism of action reveals the scientific potential of premium SS-31. Many traditional agents fail because they cannot cross the highly selective mitochondrial membranes. Others simply lack a specific molecular target inside the cell. SS-31 bypasses these hurdles. Its structural design is highly targeted.

Cardiolipin is a signature phospholipid located almost exclusively in the inner mitochondrial membrane. It maintains the curvature of the cristae — the folds where cellular respiration occurs. Think of cardiolipin as a structural scaffold. It holds the respiratory complexes (Complex I, II, III, and IV) and ATP synthase together in efficient supercomplexes. When these supercomplexes align correctly, electrons flow smoothly, maximizing ATP production and preventing electron leakage.

Cellular stress, aging, and disease cause cardiolipin to undergo peroxidation. Oxidized cardiolipin loses its structural integrity. The respiratory supercomplexes disassemble. This triggers a negative cascade: Disrupted electron flow causes a sharp drop in ATP production. Electron leakage increases, generating massive amounts of ROS. * The mitochondrial permeability transition pore (mPTP) opens, releasing cytochrome c and triggering apoptotic pathways.

SS-31 stops this destructive cycle. With its alternating basic and aromatic amino acids, it penetrates cell membranes and binds to cardiolipin via electrostatic and hydrophobic interactions. This binding protects cardiolipin from peroxidation and helps rebuild disrupted respiratory supercomplexes. By restoring the inner mitochondrial membrane architecture, SS-31 brings back membrane potential, increases ATP synthesis, and lowers ROS to normal levels. It does not reduce ROS below healthy homeostatic baselines, keeping essential signaling pathways intact.

Key Research Benefits and Investigational Areas of SS-31

The implications of cardiolipin stabilization are broad. This makes SS-31 a highly sought-after compound across scientific disciplines. Researchers purchasing SS-31 online from Champion Peptides generally focus on several key areas of cellular biology.

Cardiovascular Health and Ischemia-Reperfusion Injury

Cardiovascular medicine is a major area of study for this peptide. During a heart attack or stroke, tissues lose oxygen. When blood flow returns — known as reperfusion — a sudden influx of oxygen causes a massive burst of mitochondrial ROS, leading to tissue damage. This is ischemia-reperfusion (I/R) injury. Preclinical studies show that administering SS-31 before or during reperfusion reduces this damage. By protecting cardiolipin, SS-31 preserves myocardial structure and reduces infarct size. Current research looks at how it might improve outcomes in organ transplantation and microvascular dysfunction.

Neurodegenerative Disease and Cognitive Decline

The brain is highly active. It consumes a massive portion of total oxygen and glucose to maintain synaptic transmission. Neurons depend entirely on functional mitochondria and are vulnerable to mitochondrial decay. Conditions like Alzheimer’s, Parkinson’s, and ALS involve mitochondrial dysfunction and high oxidative stress. In animal models, SS-31 crosses the blood-brain barrier. It localizes in neuronal mitochondria. Research shows it helps preserve synaptic plasticity, reduces amyloid-beta accumulation, and protects dopaminergic neurons, offering pathways to study cognitive decline mitigation.

Renal Protection and Nephropathy

Kidneys require huge amounts of ATP to drive filtration and active transport, making them rich in mitochondria. Acute kidney injury, diabetic nephropathy, and age-related renal decline are tied to mitochondrial damage and cardiolipin loss. In vivo research shows SS-31 provides strong protective effects in renal tissues. It helps prevent endothelial fenestration loss, reduces podocyte injury, and prevents tubular cell apoptosis, preserving filtration rates in animal models.

Skeletal Muscle Aging and Sarcopenia

Aging leads to a progressive loss of muscle mass and strength. This is sarcopenia. A major driver is the age-related decline in mitochondrial volume and efficiency within muscle fibers. This causes chronic fatigue and muscle wasting. Studies in aged animal models show SS-31 can restore mitochondrial function in senescent muscle. Researchers observed increased ATP production, lower oxidative damage to muscle proteins, and better muscle fatigue resistance. It is an important tool for studying longevity and physical frailty.

Why Choose Champion Peptides for Premium SS-31

High-level research requires pure reagents. Substandard peptides containing synthetic impurities or incorrect sequences can ruin your entire study. When looking at where to buy SS-31, Champion Peptides stands out as a leading industry source. We focus on providing high-quality SS-31. Every batch undergoes High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to verify identity and purity. We guarantee a purity rating of 99% or higher, giving you a clean, active compound free of contaminants.

We also understand that research budgets matter. We work hard to keep our SS-31 price competitive without compromising our synthesis or purification processes. When you buy SS-31 online from Champion Peptides, you get reliable customer support, secure packaging, and fast shipping.

Product Specifications and Variations: 50MG

Champion Peptides offers SS-31 in a stable, lyophilized powder format inside a 50MG vial.

• Product Name: SS-31 (Elamipretide / Bendavia)
• Vial Size: 50MG
• Molecular Formula: C32H49N9O5
• Molecular Weight: 639.8 g/mol
• Purity: >99% (verified by HPLC & MS)
• Physical State: Lyophilized white powder
• Storage Conditions: Store at -20°C for long-term stability; keep dry and away from light.

The 50MG variation provides a versatile quantity for both in vitro assays and multi-dose in vivo studies. Lyophilization ensures chemical stability during shipping and storage, preventing degradation.

Reconstitution and Storage Instructions

Reconstitution Protocol

1. Temperature Equilibration: Allow the lyophilized SS-31 50MG vial to reach room temperature (20°C to 25°C) before reconstituting. This prevents moisture from condensing inside, which can degrade the peptide.
2. Sanitization: Clean the rubber stopper with an isopropyl alcohol swab and let it air dry.
3. Diluent Selection: Sterile Bacteriostatic Water (0.9% benzyl alcohol) or sterile Normal Saline (0.9% NaCl) works best. Bacteriostatic water is recommended if you plan to use the solution multiple times, as the benzyl alcohol inhibits bacterial growth.
4. Infiltration: Slowly introduce the diluent into the vial using a sterile syringe. For a 50MG vial, adding 5mL of diluent yields a concentration of 10mg/mL. Aim the liquid stream at the glass wall rather than directly at the powder to avoid aggressive agitation.
5. Dissolution: Swirl the vial gently. Do not shake. Shaking causes shear stress that can damage the peptide structure. Swirl until the powder dissolves completely into a clear, colorless liquid.

Storage and Stability

• Lyophilized Powder (Unreconstituted): Keep the dry vial in a freezer at -20°C for up to 24 months. Standard refrigeration at 2°C to 8°C is acceptable for 3 to 6 months if kept away from light and moisture.
• Reconstituted Solution: Once reconstituted, keep the solution in a refrigerator at 2°C to 8°C. Use it within 14 to 21 days for optimal stability.
• Avoid Freeze-Thaw Cycles: Aliquot the reconstituted solution into single-use sterile tubes and freeze them at -20°C or -80°C if you do not plan to use it quickly. Thaw one aliquot at a time. Do not subject reconstituted SS-31 to repeated freeze-thaw cycles, as this degrades the peptide bonds.

Key Features of Champion Peptides SS-31

• Targeted Mitochondrial Localization: Binds directly to cardiolipin in the inner mitochondrial membrane, bypassing the limits of non-targeted antioxidants.
• Enhanced ATP Synthesis: Optimizes the electron transport chain to restore cellular respiration and energy production in damaged tissues.
• Precise ROS Regulation: Lowers pathological oxidative stress and electron leakage without disrupting essential physiological signaling.
• Ultra-High Purity Guarantee: Verified at >99% purity via HPLC and Mass Spectrometry for clean, reproducible data.
• Stable Lyophilized Formulation: Packaged in a durable 50MG vial designed to withstand transit and maintain stability.
• Excellent Bioavailability: Easily crosses cell membranes and the blood-brain barrier for systemic and localized models.
• Trusted Scientific Source: Champion Peptides is a preferred vendor for researchers seeking high-quality SS-31 with fast shipping.

Frequently Asked Questions and Purchasing Details

What is SS-31, and how does it differ from other peptides?
SS-31 (Elamipretide) is a synthetic, cell-permeable tetrapeptide that targets mitochondria. Most peptides act on cell-surface receptors to trigger signaling pathways. SS-31 is different. It penetrates the cell and localizes directly to the inner mitochondrial membrane. Its main action is physical rather than receptor-mediated. By binding to cardiolipin, it stabilizes mitochondrial cristae and restores electron transport chain efficiency.

Why is cardiolipin stabilization so important in research?
Cardiolipin is essential for the structural integrity of the inner mitochondrial membrane. When cardiolipin is damaged by oxidative stress, mitochondria cannot produce ATP efficiently. They leak excessive reactive oxygen species, leading to cell death. Stabilizing cardiolipin addresses the root cause of mitochondrial decay. This makes SS-31 a valuable tool for studying aging, cardiovascular diseases, and metabolic issues.

Where is the best place to buy SS-31 online?
When looking for where to buy SS-31, Champion Peptides is a top online source for researchers globally. We synthesize high-purity research peptides under strict laboratory controls. Every vial of our SS-31 is subjected to rigorous quality testing to guarantee its purity, identity, and concentration.

What is the purity level of Champion Peptides SS-31?
Every batch of SS-31 for sale on our website is guaranteed to have a purity level of 99% or higher. We verify this through HPLC and Mass Spectrometry analysis. We believe in transparency, making our analytical reports available to researchers to ensure confidence in their materials.

How is the SS-31 price determined, and do you offer bulk discounts?
Our SS-31 price is highly competitive and reflects the quality, purification, and extensive testing that goes into every vial. Large-scale research projects require significant quantities, so we offer tiered pricing and bulk discounts. Contact our support team for a custom quote on bulk orders.

Can SS-31 be used for human consumption?
No. The SS-31 offered by Champion Peptides is strictly intended for laboratory research and development purposes, including in vitro and in vivo animal studies. It is not approved for human clinical use, diagnostic procedures, or therapeutic administration. All research must be conducted by qualified professionals in a laboratory setting.

How should I store the SS-31 50MG vial upon arrival?
Upon arrival, place the lyophilized SS-31 50MG vial in a freezer set to -20°C for long-term storage. Keep the vial away from direct light and moisture. For short-term use, storage in a standard refrigerator at 2°C to 8°C is acceptable.

What is the recommended diluent for reconstituting SS-31?
The best diluents for reconstituting lyophilized SS-31 are sterile Bacteriostatic Water (0.9% benzyl alcohol) or sterile Normal Saline (0.9% NaCl). Bacteriostatic water is preferred if you plan to store the reconstituted solution in the refrigerator for multiple uses over several weeks, as the preservative prevents microbial contamination.

How do I order SS-31 online from Champion Peptides?
To order SS-31 online, select the 50MG variation on this page, choose your quantity, and add it to your cart. Our secure checkout accepts several payment methods. Once placed, your order is carefully packaged in temperature-controlled, insulated packaging. We offer fast, trackable shipping to accommodate your research timelines.